CHEBI:45716 - vorinostat

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ChEBI Name vorinostat
ChEBI ID CHEBI:45716
Definition A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB3506806, eMolecules:1989084, Selleckchem:Vorinostat-(SAHA), ZINC000001543873
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Roles Classification
Biological Role(s): EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
vorinostat is a Structural Derivative of
suberic acid
Mass : 174.19436
Formula : C8H14O4
9300 		hydroxylamine
Mass : 33.02996
Formula : H3NO
15429 		aniline
Mass : 93.12650
Formula : C6H7N
17296
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carbamoyl group
molecular entity
dicarboxylic acid amide
chemical entity
hydroxamic acid
oxygen molecular entity
amide
primary amide
heteroorganic entity
pnictogen molecular entity
chalcogen molecular entity
main group molecular entity
carbon group molecular entity
p-block molecular entity
organonitrogen compound
dicarboxylic acid diamide
organochalcogen compound
organooxygen compound
carboxamide
vorinostat
organic molecular entity
nitrogen molecular entity
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