CHEBI:16831 - 3-hydroxy-3-methylglutaric acid

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ChEBI Name 3-hydroxy-3-methylglutaric acid
ChEBI ID CHEBI:16831
Definition A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:391, CHEBI:1524, CHEBI:20043, CHEBI:43804, CHEBI:11044, CHEBI:30919, CHEBI:18746
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
antimetabolite
A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
Related Structures
3-hydroxy-3-methylglutaric acid is a Functional Parent of
viscumneoside VII
Mass : 768.671
Formula : C34H40O20
132861
viscumneoside IV
Mass : 636.556
Formula : C29H32O16
132858
yanuthone D
Mass : 502.598
Formula : C28H38O8
133841
yanuthone E
Mass : 504.613
Formula : C28H40O8
133840
dianversicoside B
Mass : 1295.37040
Formula : C60H94O30
65756
dianversicoside C
Mass : 1441.51160
Formula : C66H104O34
65757
dianversicoside D
Mass : 1279.37100
Formula : C60H94O29
65758
yanuthone J
Mass : 522.629
Formula : C28H42O9
133838
dianversicoside A
Mass : 1295.37040
Formula : C60H94O30
65755
3-hydroxy-3-methylglutaryl-CoA
Mass : 911.66072
Formula : C27H44N7O20P3S
11814
licoagroside B
Mass : 432.377
Formula : C18H24O12
142266
3-hydroxy-3-methylglutaric acid is a Structural Derivative of
glutaric acid
Mass : 132.11462
Formula : C5H8O4
17859
3-hydroxy-3-methylglutaric acid is a Conjugate Acid of
3-hydroxy-3-methylglutarate(1-)
Mass : 161.13270
Formula : C6H9O5
30920
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