CHEBI:134689 - rucaparib

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ChEBI Name rucaparib
ChEBI ID CHEBI:134689
Definition A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:94311
Supplier Information ChemicalBook:CB51475507, ZINC000000025958
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD+ ADP-ribosyltransferase (EC 2.4.2.30).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
rucaparib is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
rucaparib is a Conjugate Base of
rucaparib(1+)
Mass : 324.373
Formula : C19H19FN3O
134695
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rucaparib
azepinoindole
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