CHEBI:135029 - cycloguanil

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ChEBI Name cycloguanil
ChEBI ID CHEBI:135029
Definition A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Biological Role(s): EC 1.5.1.3 (dihydrofolate reductase) inhibitor
An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
antimalarial
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
antifolate
An antimetabolite that impairs the action of folic acids
Application(s): antiinfective agent
A substance used in the prophylaxis or therapy of infectious diseases.
antiparasitic agent
A substance used to treat or prevent parasitic infections.
antimalarial
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
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