CHEBI:141517 - tyloxapol

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ChEBI Name tyloxapol
ChEBI ID CHEBI:141517
Definition A polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Sabrina Toro
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Roles Classification
Chemical Role(s): surfactant
A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
inhibitor
A substance that diminishes the rate of a chemical reaction.
Application(s): excipient
A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication.
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has functional parent
has parent hydride
is substituent group from
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