CHEBI:145428 - glasdegib

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ChEBI Name glasdegib
ChEBI ID CHEBI:145428
Definition A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a (2R,4S)-4-{[(4-cyanophenyl)carbamoyl]amino}-1-methylpiperidin-2-yl group at position 2. It is a hedgehog signalling pathway inhibitor that acts by binding to Smoothened (SMO) receptors and blocking signal transduction (IC50 = 5 nM). It is used in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients (aged ≥ 75 years), or who have medical conditions that prevent the use of standard chemotherapy.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Biological Role(s): SMO receptor antagonist
An antagonist that interferes with the action of smoothened (SMO) receptor.
Hedgehog signaling pathway inhibitor
Any pathway inhibitor that inhibits the Hedgehog signalling pathway.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
glasdegib is a Structural Derivative of
urea
Mass : 60.05534
Formula : CH4N2O
16199 		hydrogen cyanide
Mass : 27.02530
Formula : CHN
18407
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has part
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is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
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