CHEBI:156259 - PD-166866

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ChEBI Name PD-166866
ChEBI ID CHEBI:156259
Definition A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Ceri
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
Related Structures
PD-166866 is a Functional Parent of
PD173074
Mass : 523.67020
Formula : C28H41N7O3
63448
PD-166866 is a Structural Derivative of
urea
Mass : 60.05534
Formula : CH4N2O
16199 		ammonia
Mass : 17.03056
Formula : H3N
16134
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