CHEBI:167314 - KOM70144

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ChEBI Name KOM70144
ChEBI ID CHEBI:167314
Definition A benzamide that is GRL-0617 in which one of the hydrogen's of the primary amino group is replaced by an acetyl group. It an inhibitor of SARS-CoV and SARS-CoV-2 papain-like protease (PLpro) with an IC50 of 2.6 μM and 5.0 μM, respectively. It also inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 μM, respectively).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
Supplier Information
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Roles Classification
Biological Role(s): protease inhibitor
A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
Related Structures
KOM70144 is a Structural Derivative of
GRL-0617
Mass : 304.393
Formula : C20H20N2O
167176
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Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
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