CHEBI:167663 - MI-1148

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ChEBI Name MI-1148
ChEBI ID CHEBI:167663
Definition A tripeptide comprising of L-arginine, 3-methyl-L-valine and L-arginine joined in sequence by peptide linkages and in which the amino terminus is substituted by a [4-(carbamimidamidomethyl)phenyl]acetyl group and the carboxy terminus is substituted by a (4-carbamimidoylbenzyl)amino group. It is a highly potent inhibitor of furin endoprotease (Ki = 5.5 pM) that has anti-infectious activity.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter R. Stephan
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): peptidomimetic
A small protein-like chain designed to mimic a peptide.
EC 3.4.21.75 (furin) inhibitor
An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of furin (EC 3.4.21.75).
antiviral agent
A substance that destroys or inhibits replication of viruses.
antibacterial agent
A substance (or active part thereof) that kills or slows the growth of bacteria.
Related Structures
MI-1148 is a Structural Derivative of
L-arginine
Mass : 174.20100
Formula : C6H14N4O2
16467 		ammonia
Mass : 17.03056
Formula : H3N
16134
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Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
Status
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