CHEBI:173086 - ferrostatin-1

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ChEBI Name ferrostatin-1
ChEBI ID CHEBI:173086
Definition An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): ferroptosis inhibitor
Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
Application(s): radiation protective agent
Any compound that is able to protect normal cells from the damage caused by radiation therapy.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
Related Structures
ferrostatin-1 is a Functional Parent of
SRS11-92
Mass : 352.478
Formula : C22H28N2O2
173095
ferrostatin-1 is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134 		carboxylic acid
Mass : 45.017
Formula : CHO2R
33575 		ethanol
Mass : 46.06844
Formula : C2H6O
16236
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