CHEBI:192483 - BAY-826

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name BAY-826
ChEBI ID CHEBI:192483
Definition A secondary carboxamide resulting from the formal condensation of the carboxy group of 3-cyano-5-(pentafluoro-λ6-sulfanyl)benzoic acid with the amino group of 2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline. It is a potent TIE-2 inhibitor (Kd = 1.6 nM) which displays in vivo efficacy in some murine glioma models.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter TheOtherDave
Supplier Information
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Roles Classification
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
BAY-826 is a Structural Derivative of
hydrogen cyanide
Mass : 27.02530
Formula : CHN
18407
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