CHEBI:229217 - nirogacestat

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ChEBI Name nirogacestat
ChEBI ID CHEBI:229217
Definition A member of the class of imidazoles that is 1H-imidazole substituted by a 1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl group at position 1 and a {N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-L-norvalyl}amino group at position 4. It is a γ-secretase inhibitor whose hydrobromide salt is indicated for adult patients with progressing desmoid tumours who require systemic treatment.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): gamma-secretase modulator
A modulator of gamma-secretase, one of the three endopeptidases that are specific for amyloid protein precursor and which have been identified based upon the region of the amyloid protein precursor which they cleave.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
nirogacestat is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
nirogacestat is a Conjugate Base of
nirogacestat(2+)
Mass : 491.671
Formula : C27H43F2N5O
229219
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