CHEBI:229938 - GDC-0326

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name GDC-0326
ChEBI ID CHEBI:229938
Definition An organic heterotricyclic compound that is 5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine substituted by 1-(propan-2-yl)-1H-1,2,4-triazol-5-yl and [(2S)-1-amino-1-oxopropan-2-yl]oxy groups at positions 2 and 9, respectively. It is a potent and selective inhibitor of PI3Kα (Ki = 0.2 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Doug Howe
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
GDC-0326 is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
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