CHEBI:231347 - triapine

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ChEBI Name triapine
ChEBI ID CHEBI:231347
Definition A thiosemicarbazone resulting from the formal condensation of the formyl group of 3-aminopicolinaldehyde with the non-thioacylated amino group of hydrazinecarbothioamide. It is a ribonucleotide reductase inhibitor that exhibits anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Delphine Zhou
Supplier Information
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Roles Classification
Chemical Role(s): iron chelator

Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
radiosensitizing agent
A drug that makes increases the sensitivity of tumour cells to radiation therapy.
Related Structures
triapine is a Structural Derivative of
3-aminopicolinaldehyde
Mass : 122.127
231207 		ammonia
Mass : 17.03056
Formula : H3N
16134 		semicarbazone
Mass : 82.041
Formula : C2N3OR5
87210
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