CHEBI:231658 - PF-06409577

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ChEBI Name PF-06409577
ChEBI ID CHEBI:231658
Definition A chloroindole that is 6-chloro-1H-indole substituted by carboxy and 4-(1-hydroxycyclobutyl)phenyl groups at positions 3 and 5, respectively. It is a potent and selective allosteric activator of AMPK and a potential treatment for diabetic nephropathy.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Rui Xiang Yu
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator
Any compound that binds to and activates the enzyme [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31).
Application(s): antiatherosclerotic agent
A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
nephroprotective agent
Any protective agent that is able to prevent damage to the kidney.
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