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ChEBI
> ChEBI Ontology
CHEBI:2639 - amiloride
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ChEBI Ontology
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ChEBI Name
amiloride
ChEBI ID
CHEBI:2639
Definition
A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Stars
This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs
CHEBI:47210
Supplier Information
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Roles Classification
Chemical Role
(s):
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
sodium channel blocker
An agent that inhibits sodium influx through cell membranes.
Application
(s):
diuretic
An agent that promotes the excretion of urine through its effects on kidney function.
Related Structures
amiloride is a
Functional Parent
of
5-(N,N-hexamethylene)amiloride
Mass : 311.77100
Formula : C12H18ClN7O
5-(N-methyl-N-propyl)amiloride
Mass : 285.734
Formula : C10H16ClN7O
ethylisopropylamiloride
Mass : 299.760
Formula : C11H18ClN7O
amiloride is a
Structural Derivative
of
ammonia
Mass : 17.03056
Formula : H3N
amiloride is a
Conjugate Base
of
amiloride(1+)
Mass : 230.63400
Formula : C6H9ClN7O
Graph View
Tree View
CHEBI:24431 chemical entity
CHEBI:23367 molecular entity
CHEBI:33579 main group molecular entity
CHEBI:33675 p-block molecular entity
CHEBI:33582 carbon group molecular entity
CHEBI:50860 organic molecular entity
CHEBI:72695 organic molecule
CHEBI:33832 organic cyclic compound
CHEBI:24532 organic heterocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33659 organic aromatic compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33285 heteroorganic entity
CHEBI:24532 organic heterocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:35352 organonitrogen compound
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:50047 organic amino compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:24436 guanidines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:17792 organohalogen compound
CHEBI:36683 organochlorine compound
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:50047 organic amino compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33302 pnictogen molecular entity
CHEBI:51143 nitrogen molecular entity
CHEBI:35352 organonitrogen compound
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:50047 organic amino compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:24436 guanidines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:24471 halogen molecular entity
CHEBI:37578 halide
CHEBI:17792 organohalogen compound
CHEBI:36683 organochlorine compound
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:23117 chlorine molecular entity
CHEBI:36683 organochlorine compound
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:36357 polyatomic entity
CHEBI:25367 molecule
CHEBI:33595 cyclic compound
CHEBI:5686 heterocyclic compound
CHEBI:24532 organic heterocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33670 heteromonocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33832 organic cyclic compound
CHEBI:24532 organic heterocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33659 organic aromatic compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33661 monocyclic compound
CHEBI:33670 heteromonocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33655 aromatic compound
CHEBI:33659 organic aromatic compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:72695 organic molecule
CHEBI:33832 organic cyclic compound
CHEBI:24532 organic heterocyclic compound
CHEBI:25693 organic heteromonocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:38101 organonitrogen heterocyclic compound
CHEBI:38313 diazines
CHEBI:38314 pyrazines
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33659 organic aromatic compound
CHEBI:33860 aromatic amine
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:37577 heteroatomic molecular entity
CHEBI:37578 halide
CHEBI:17792 organohalogen compound
CHEBI:36683 organochlorine compound
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:50906 role
CHEBI:24432 biological role
CHEBI:52208 biophysical role
CHEBI:38632 membrane transport modulator
CHEBI:39000 sodium channel modulator
CHEBI:38633 sodium channel blocker
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
CHEBI:33232 application
CHEBI:52217 pharmaceutical
CHEBI:23888 drug
CHEBI:35498 diuretic
CHEBI:2639 amiloride
CHEBI:84745 amiloride(1+)
CHEBI:84745 amiloride(1+)
CHEBI:76400 5-(
N
,
N
-hexamethylene)amiloride
CHEBI:138016 5-(
N
-methyl-
N
-propyl)amiloride
CHEBI:136538 ethylisopropylamiloride
Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
Status
Checked
Unchecked