CHEBI:34967 - rimonabant

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ChEBI Name rimonabant
ChEBI ID CHEBI:34967
Definition A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): anti-obesity agent
Any substance which is used to reduce or control weight.
CB1 receptor antagonist
An antagonist that binds to and deactivates type 1 cannabinoid receptors.
Application(s): appetite depressant
Any agent that is used to decrease appetite.
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