CHEBI:42142 - Ac-(D)Phe-Pro-boroArg-OH

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ChEBI Name Ac-(D)Phe-Pro-boroArg-OH
ChEBI ID CHEBI:42142
ChEBI ASCII Name Ac-(D)Phe-Pro-boroArg-OH
Definition A C-terminal boronic acid petide that is N-acetyl-D-phenylalanyl-L-prolyl-L-arginine in which the C-termnal carboxy group has been replaced by a borono (-B(OH)2) group. A thrombin (Factor IIa) inhibitor, thereby acting as an anticoagulant.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): EC 3.4.21.5 (thrombin) inhibitor
An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of thrombin (EC 3.4.21.5).
Application(s): anticoagulant
An agent that prevents blood clotting.
Related Structures
Ac-(D)Phe-Pro-boroArg-OH is a Structural Derivative of
peptide
Definition : Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
Ac-(D)Phe-Pro-boroArg-OH is a Conjugate Base of
Ac-(D)Phe-Pro-boroArg-OH(1+)
Mass : 461.344
Formula : C21H34BN6O5
140518
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