CHEBI:4317 - dantrolene

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ChEBI Name dantrolene
ChEBI ID CHEBI:4317
Definition The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Biological Role(s): ryanodine receptor antagonist
A ryanodine receptor modulator which deactivates the receptor.
Application(s): muscle relaxant
A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
Related Structures
dantrolene is a Conjugate Acid of
dantrolene(1-)
Mass : 313.250
Formula : C14H9N4O5
59697
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