CHEBI:44423 - hydroxyurea

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ChEBI Name hydroxyurea
ChEBI ID CHEBI:44423
Definition A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:44420, CHEBI:5816
Supplier Information
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Roles Classification
Chemical Role(s): radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
Biological Role(s): DNA synthesis inhibitor
Any substance that inhibits the synthesis of DNA.
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1).
genotoxin
A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
antimetabolite
A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
teratogenic agent
A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
antimitotic
Any compound that inhibits cell division (mitosis).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Related Structures
hydroxyurea is a Structural Derivative of
urea
Mass : 60.05534
Formula : CH4N2O
16199
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