CHEBI:45783 - imatinib

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ChEBI Name imatinib
ChEBI ID CHEBI:45783
Definition A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:305376, CHEBI:38918, CHEBI:45781
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
imatinib is a Functional Parent of
linkable imatinib analogue
Mass : 522.64428
Formula : C30H34N8O
39083
imatinib is a Structural Derivative of
benzamide
Mass : 121.13662
Formula : C7H7NO
28179 		ammonia
Mass : 17.03056
Formula : H3N
16134
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Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
Status
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Unchecked