CHEBI:47381 - diclofenac

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ChEBI Name diclofenac
ChEBI ID CHEBI:47381
Definition A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:47380, CHEBI:4507
Supplier Information
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Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
drug allergen
Any drug which causes the onset of an allergic reaction.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
drug allergen
Any drug which causes the onset of an allergic reaction.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
Related Structures
diclofenac is a Functional Parent of
diclofenac beta-D-glucosiduronic acid
Mass : 472.27300
Formula : C20H19Cl2NO8
59609
4'-hydroxydiclofenac quinone imine
Mass : 310.13200
Formula : C14H9Cl2NO3
59610
5-hydroxydiclofenac quinone imine
Mass : 310.13200
Formula : C14H9Cl2NO3
59611
5-hydroxydiclofenac
Mass : 312.14800
Formula : C14H11Cl2NO3
59612
4'-hydroxydiclofenac
Mass : 312.14800
Formula : C14H11Cl2NO3
59613
3'-hydroxydiclofenac
Mass : 312.14800
Formula : C14H11Cl2NO3
223792
4',5-dihydroxydiclofenac
Mass : 328.14700
Formula : C14H11Cl2NO4
223401
3'-hydroxy-4'-methoxydiclofenac
Mass : 342.17400
Formula : C15H13Cl2NO4
223404
aceclofenac
Mass : 354.18500
Formula : C16H13Cl2NO4
31159
diclofenac is a Structural Derivative of
phenylacetic acid
Mass : 136.14792
Formula : C8H8O2
30745
diphenylamine
Mass : 169.22248
Formula : C12H11N
4640
ammonia
Mass : 17.03056
Formula : H3N
16134
diclofenac is a Conjugate Acid of
diclofenac(1-)
Mass : 295.14014
Formula : C14H10Cl2NO2
48311
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