CHEBI:49490 - AZD7545

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name AZD7545
ChEBI ID CHEBI:49490
Definition A sulfone that is benzene substituted by [4-(dimethylcarbamoyl)phenyl]sulfonyl, chloro and [(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino groups at positions 1, 3 and 4, respectively. It is a potent and non-ATP-competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2) with IC50 of 6.4 nM and exhibits glucose-lowering activity. Also inhibits PDHK1 at higher levels (IC50 = 36.8 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Roles Classification
Biological Role(s): EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of pyruvate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.2).
Application(s): hypoglycemic agent
A drug which lowers the blood glucose level.
Graph View Tree View
panning
Move up
Move left
Move down
Move right
Graph compression

Simplified view Show me the possible minimal nodes in this graph
Full view Show me all the nodes in this graph
Personalised view Create your own personalised ontology view, if you wish to remove any entity from your future visualisations please right click the entity (e.g. molecular entity)
My hidden entities
Edit
+Zoom in
-Zoom out
Download
Enter fullscreen