CHEBI:49960 - vandetanib

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name vandetanib
ChEBI ID CHEBI:49960
Definition A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:38942, CHEBI:49959
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
vandetanib is a Functional Parent of
linkable vandetanib analogue
Mass : 435.29026
Formula : C19H20BrFN4O2
39080
vandetanib is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
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