CHEBI:52717 - bortezomib

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ChEBI Name bortezomib
ChEBI ID CHEBI:52717
Definition L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at Nα by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:41143
Supplier Information
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Roles Classification
Biological Role(s): protease inhibitor
A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
Related Structures
bortezomib is a Structural Derivative of
boronic acid
Mass : 45.83362
Formula : BH3O2
38267 		L-phenylalanine
Mass : 165.18918
Formula : C9H11NO2
17295 		phenylalanine
Mass : 165.18918
Formula : C9H11NO2
28044 		proteinogenic amino acid
Definition : Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.
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is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
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