CHEBI:63115 - fingolimod

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ChEBI Name fingolimod
ChEBI ID CHEBI:63115
Definition An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): sphingosine-1-phosphate receptor agonist
An agonist that binds to and activates sphingosine 1-phosphate receptors.
CB1 receptor antagonist
An antagonist that binds to and deactivates type 1 cannabinoid receptors.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
Related Structures
fingolimod is a Functional Parent of
fingolimod phosphate
Mass : 387.45070
Formula : C19H34NO5P
73420 		2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol
Mass : 321.505
Formula : C20H35NO2
167708
fingolimod is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
fingolimod is a Conjugate Base of
fingolimod(1+)
Mass : 308.47880
Formula : C19H34NO2
63113
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Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
Status
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