CHEBI:63587 - eribulin

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ChEBI Name eribulin
ChEBI ID CHEBI:63587
Definition A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): microtubule-destabilising agent
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
eribulin is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
eribulin is a Conjugate Base of
eribulin(1+)
Mass : 730.90450
Formula : C40H60NO11
70711
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