CHEBI:64153 - tanespimycin

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ChEBI Name tanespimycin
ChEBI ID CHEBI:64153
Definition A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): Hsp90 inhibitor
An EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
tanespimycin is a Structural Derivative of
geldanamycin
Mass : 560.63590
Formula : C29H40N2O9
5292 		ammonia
Mass : 17.03056
Formula : H3N
16134 		carbamic acid
Mass : 61.04006
Formula : CH3NO2
28616
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