CHEBI:65484 - bevirimat

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name bevirimat
ChEBI ID CHEBI:65484
Definition A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): HIV-1 maturation inhibitor
A compound that blocks the processing of the Gag precursor protein in HIV-1 by the viral protease enzyme, leading to the formation of noninfectious, immature virus particles that are incapable of infecting other cells.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Related Structures
bevirimat is a Structural Derivative of
betulinic acid
Mass : 456.70030
Formula : C30H48O3
3087 		triterpene
Definition : A C30 terpene.
 terpene
Definition : A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH22C(CH3)CH2CH2].
Graph View Tree View
Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
Status
Checked
Unchecked