CHEBI:71954 - BKM120

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ChEBI Name BKM120
ChEBI ID CHEBI:71954
Definition An aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Bijay
Supplier Information ChemicalBook:CB02561459, ChemicalBook:CB82509983, eMolecules:36000448, Selleckchem:BKM-120, ZINC000043154039
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
BKM120 is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134
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heterocyclic compound
organohalogen compound
molecular entity
fluorine atom
fluorine molecular entity
chemical entity
halogen molecular entity
organic heterocyclic compound
molecule
organic heteromonocyclic compound
oxygen molecular entity
pyridines
heteroorganic entity
pnictogen molecular entity
chalcogen molecular entity
main group molecular entity
carbon group molecular entity
cyclic compound
aromatic compound
organic aromatic compound
monocyclic compound
heteromonocyclic compound
p-block molecular entity
organic cyclic compound
aromatic amine
organonitrogen compound
polyatomic entity
organochalcogen compound
organooxygen compound
organofluorine compound
heteroatomic molecular entity
halide
organonitrogen heterocyclic compound
oxacycle
aminopyridine
diazines
aminopyrimidine
morpholines
pyrimidines
oxazinane
organic amino compound
organic molecular entity
nitrogen molecular entity
BKM120
organic molecule
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