CHEBI:7459 - naloxone

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ChEBI Name naloxone
ChEBI ID CHEBI:7459
Definition A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Biological Role(s): mu-opioid receptor antagonist
Any compound that exhibits antagonist activity at the mu-opioid receptor
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Application(s): mu-opioid receptor antagonist
Any compound that exhibits antagonist activity at the mu-opioid receptor
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
antidote to opioid poisoning
A role borne by a molecule that acts to counteract or neutralise the deleterious effects of opioids.
Related Structures
naloxone is a Functional Parent of
naloxegol
Mass : 651.78470
Formula : C34H53NO11
82975
naloxone is a Structural Derivative of
morphinan
Mass : 227.34468
Formula : C16H21N
35649
naloxone is a Conjugate Base of
naloxone(1+)
Mass : 328.383
Formula : C19H22NO4
90756
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