CHEBI:77734 - dexverapamil

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ChEBI Name dexverapamil
ChEBI ID CHEBI:77734
Definition A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44).
Related Structures
dexverapamil is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134 		hydrogen cyanide
Mass : 27.02530
Formula : CHN
18407
dexverapamil is a Conjugate Base of
dexverapamil(1+)
Mass : 455.60900
Formula : C27H39N2O4
77737
dexverapamil is a Enantiomer of
(S)-verapamil
Mass : 454.60160
Formula : C27H38N2O4
77736
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Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
Status
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