CHEBI:82818 - Z-Val-Phe-H

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ChEBI Name Z-Val-Phe-H
ChEBI ID CHEBI:82818
Definition A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpain I and II, and is also a γ-secretase inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 3.4.22.53 (calpain-2) inhibitor
A calpain inhibitor that interferes with the action of calpain-2 (EC 3.4.22.53).
EC 3.4.22.52 (calpain-1) inhibitor
A calpain inhibitor that interferes with the action of calpain-1 (EC 3.4.22.52).
EC 3.4.23.46 (memapsin 2) inhibitor
An EC 3.4.23.* (aspartic endopeptidase) inhibitor that interferes with the activity of memapsin 2 (EC 3.4.23.46).
antileishmanial agent
An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
apoptosis inhibitor
Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antileishmanial agent
An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
Related Structures
Z-Val-Phe-H is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134 		carbamic acid
Mass : 61.04006
Formula : CH3NO2
28616
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