CHEBI:88249 - PD 0325901

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ChEBI Name PD 0325901
ChEBI ID CHEBI:88249
Definition A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor
An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of mitogen-activated protein kinase kinase (EC 2.7.12.2).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
PD 0325901 is a Structural Derivative of
hydroxamic acid
Definition : A compound, RkE(2O)lNHOH, derived from an oxoacid RkE(2O)l(OH) (l 0) by replacing 1OH with 1NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides.
 ammonia
Mass : 17.03056
Formula : H3N
16134
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