CHEBI:90739 - BMS-453

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ChEBI Name BMS-453
ChEBI ID CHEBI:90739
Definition A member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer). It is a potent retinoic acid receptor γ (RARβ) agonist that acts as an antagonist against RARα and RARγ.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): teratogenic agent
A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
retinoic acid receptor beta agonist
Any retinoic acid receptor (RAR) agonist with specificity for RARbeta.
retinoic acid receptor gamma antagonist
A retinoic acid receptor antagonist that antagonises retinoic acid receptor gamma.
retinoic acid receptor alpha antagonist
A retinoic acid receptor antagonist that antagonises retinoic acid receptor alpha.
Application(s): retinoic acid receptor beta agonist
Any retinoic acid receptor (RAR) agonist with specificity for RARbeta.
retinoic acid receptor gamma antagonist
A retinoic acid receptor antagonist that antagonises retinoic acid receptor gamma.
retinoic acid receptor alpha antagonist
A retinoic acid receptor antagonist that antagonises retinoic acid receptor alpha.
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