CHEBI:90848 - ACT-333679

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ChEBI Name ACT-333679
ChEBI ID CHEBI:90848
Definition A member of the class of pyrazines that is {4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetic acid carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. The active metabolite of selexipag, an orphan drug used for the treatment of pulmonary arterial hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): prostacyclin receptor agonist
An agonist that binds to and activates prostacyclin receptors
drug metabolite

Application(s): orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
vasodilator agent
A drug used to cause dilation of the blood vessels.
Related Structures
ACT-333679 is a Functional Parent of
selexipag
Mass : 496.624
Formula : C26H32N4O4S
90844
ACT-333679 is a Structural Derivative of
ammonia
Mass : 17.03056
Formula : H3N
16134 		sulfonic acid
Mass : 82.08008
Formula : H2O3S
29214 		oxoacid
Definition : A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
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Relationship Types
is a
has part
is conjugate base of
is conjugate acid of
is tautomer of
is enantiomer of
has functional parent
has parent hydride
is substituent group from
has role
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