CHEBI:90939 - ixazomib citrate

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ChEBI Name ixazomib citrate
ChEBI ID CHEBI:90939
Definition A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of 2,2'-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid. A prodrug for ixazomib that is used in combination therapy for treatment of multiple myeloma.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
ixazomib citrate is a Structural Derivative of
ixazomib
Mass : 361.029
Formula : C14H19BCl2N2O4
90942 		glycine
Mass : 75.06664
Formula : C2H5NO2
15428 		proteinogenic amino acid
Definition : Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.
 boronic acid
Mass : 45.83362
Formula : BH3O2
38267
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