CHEBI:90954 - MCB-613

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ChEBI Name MCB-613
ChEBI ID CHEBI:90954
Definition A cyclic ketone that is 4-ethylcyclohexanone which is substituted by pyridin-3-ylmethylene groups at positions 2 and 6. It is a potent small molecule stimulator of steroid receptor coactivators (SRCs). MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species. Since cancer cells overexpress SRCs and rely on them for growth, MCB-613 can be used to selectively induce excessive stress in cancer cells.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
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Roles Classification
Biological Role(s): steroid receptor coactivator stimulator
A compound that enhances the activity of a steroid receptor coactivator.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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has parent hydride
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