CHEBI:9586 - tiagabine

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ChEBI Name tiagabine
ChEBI ID CHEBI:9586
Definition A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB21431874, eMolecules:10556188, ZINC000038143761
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): GABA reuptake inhibitor
A compound that inhibits the re-uptake of the neurotransmitter GABA from the synapse into the pre-synaptic neuron, so increasing the extracellular concentrations of the neurotransmitter and hence increasing neurotransmission.
Application(s): GABA reuptake inhibitor
A compound that inhibits the re-uptake of the neurotransmitter GABA from the synapse into the pre-synaptic neuron, so increasing the extracellular concentrations of the neurotransmitter and hence increasing neurotransmission.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
Related Structures
tiagabine is a Structural Derivative of
(R)-nipecotic acid
Mass : 129.15700
Formula : C6H11NO2
221278
ammonia
Mass : 17.03056
Formula : H3N
16134
tiagabine is a Conjugate Base of
tiagabine(1+)
Mass : 376.55500
Formula : C20H26NO2S2
85387
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heterocyclic compound
tiagabine
molecular entity
chemical entity
organic heterocyclic compound
hydroxides
oxoacid
molecule
monocarboxylic acid
organic heteromonocyclic compound
oxygen molecular entity
piperidinemonocarboxylic acid
piperidines
sulfur molecular entity
thiophenes
organosulfur compound
heteroorganic entity
pnictogen molecular entity
chalcogen molecular entity
carboxylic acid
main group molecular entity
carbon group molecular entity
cyclic compound
hydrogen molecular entity
monocyclic compound
heteromonocyclic compound
s-block molecular entity
p-block molecular entity
beta-amino acid
amino acid
organic cyclic compound
organonitrogen compound
carbon oxoacid
polyatomic entity
carbonyl compound
organic oxo compound
organochalcogen compound
organooxygen compound
heteroatomic molecular entity
organonitrogen heterocyclic compound
organosulfur heterocyclic compound
organic amino compound
organic molecular entity
tertiary amino compound
nitrogen molecular entity
organic acid
organic molecule
non-proteinogenic amino acid
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