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M  END
> <ID>
CHEBI:194340

> <NAME>
apinocaltamide

> <DEFINITION>
A secondary carboxamide resulting from the formal condensation of the carboxy group of {4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetic acid with the amino group of 6-[(3-amino-1H-pyrazol-1-yl)methyl]pyridine-3-carbonitrile. It is a selective, orally available T-type calcium channel blocker that is being studied as a potential new treatment in epilepsy.

> <STAR>
3

> <SYNONYM>
N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-benzeneacetamide; ACT709478; ACT-709478; ACT 709478

> <IUPAC_NAME>
N-{1-[(5-cyanopyridin-2-yl)methyl]-1H-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide

> <INN>
apinocaltamidum; apinocaltamide; apinocaltamide; apinocaltamida

> <FORMULA>
C22H18F3N5O

> <MASS>
425.415

> <MONOISOTOPIC_MASS>
425.14634

> <CHARGE>
0

> <SMILES>
FC(F)(F)C1(CC1)C1=CC=C(CC(=O)NC2=NN(CC3=CC=C(C=N3)C#N)C=C2)C=C1

> <INCHI>
InChI=1S/C22H18F3N5O/c23-22(24,25)21(8-9-21)17-4-1-15(2-5-17)11-20(31)28-19-7-10-30(29-19)14-18-6-3-16(12-26)13-27-18/h1-7,10,13H,8-9,11,14H2,(H,28,29,31)

> <INCHIKEY>
LSYANGLAZUZYFX-UHFFFAOYSA-N

> <CAS_REGISTRY_NUMBER>
1838651-58-3

> <DRUGBANK_ACCESSION>
DB16241

> <PUBMED_CITATION>
29116786; 30372652; 31004346; 31994022; 35295464

$$$$