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M  END
> <ID>
CHEBI:145371

> <NAME>
binimetinib

> <DEFINITION>
A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the  treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.

> <STAR>
3

> <SYNONYM>
NVP-MEK162; N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide; MEK162; MEK-162; ARRY-438162; ARRY-162; ARRY 438162; ARRY 162; 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide

> <IUPAC_NAME>
5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

> <INN>
binimetinibum; binimetinib; binimetinib; binimetinib

> <BRAND_NAME>
Mektovi

> <FORMULA>
C17H15BrF2N4O3

> <MASS>
441.233

> <MONOISOTOPIC_MASS>
440.02956

> <CHARGE>
0

> <SMILES>
BrC=1C=C(F)C(NC=2C(F)=C3N=CN(C3=CC2C(=O)NOCCO)C)=CC1

> <INCHI>
InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

> <INCHIKEY>
ACWZRVQXLIRSDF-UHFFFAOYSA-N

> <CAS_REGISTRY_NUMBER>
606143-89-9

> <CHEMIDPLUS>
606143-89-9

> <DRUGBANK_ACCESSION>
DB11967

> <KEGG_DRUG_ACCESSION>
D10604

> <LINCS_ACCESSION>
LSM-45640

> <WIKIPEDIA_ACCESSION>
Binimetinib

> <PUBMED_CENTRAL_CITATION>
PMC6012544

> <PUBMED_CITATION>
23414587; 27071922; 28152546; 28412197; 28587477; 28851243; 29785570; 29946554; 30117021; 30635233; 30648436; 30652516; 30956763; 31050693; 31129802; 31213500; 31312030; 31395751; 31436845; 31437754; 31631932

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