Ketcher 07302012502D 1 1.00000 0.00000 0 29 31 0 0 0 999 V2000 13.2109 -10.2655 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.4904 -4.3056 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.7699 -7.2855 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.4904 -10.2655 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3507 -8.7755 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 14.0712 -8.7755 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.8193 -8.8100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 16.7194 -7.2649 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 17.5778 -8.7995 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3507 -9.7688 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2109 -7.2855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2109 -8.2788 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3507 -6.7889 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0712 -6.7889 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9314 -7.2855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9314 -8.2788 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4904 -7.2855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3507 -5.7955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4904 -5.2988 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6301 -6.7889 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6301 -5.7955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8193 -6.7544 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7194 -8.2996 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6301 -3.8089 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9097 -6.7889 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4904 -11.2588 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6302 -11.7556 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3507 -11.7555 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4904 -12.2522 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 10 2 0 0 0 2 19 1 0 0 0 2 24 1 0 0 0 3 20 1 0 0 0 3 25 1 0 0 0 4 10 1 0 0 0 5 10 1 0 0 0 5 12 1 0 0 0 6 12 1 0 0 0 6 16 2 0 0 0 7 16 1 0 0 0 7 23 2 0 0 0 8 22 2 0 0 0 8 23 1 0 0 0 9 23 1 0 0 0 11 12 2 0 0 0 11 13 1 0 0 0 11 14 1 0 0 0 13 17 2 0 0 0 13 18 1 0 0 0 14 15 2 0 0 0 15 16 1 0 0 0 15 22 1 0 0 0 17 20 1 0 0 0 18 19 2 0 0 0 19 21 1 0 0 0 20 21 2 0 0 0 4 26 1 0 0 0 26 27 1 0 0 0 26 28 1 0 0 0 26 29 1 0 0 0 M END > CHEBI:156259 > PD-166866 > A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM. > 3 > PD166866; PD-166866; PD 166866; N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea; 1-[2-amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea > 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea > C20H24N6O3 > 396.451 > 396.19099 > 0 > O=C(NC(C)(C)C)NC=1N=C2N=C(N=CC2=CC1C3=CC(OC)=CC(OC)=C3)N > InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) > NHJSWORVNIOXIT-UHFFFAOYSA-N > 192705-79-6 > 192705-79-6 > 11063616; 11384237; 11404258; 12805413; 15773903; 15780636; 17964795; 17987803; 20003343; 21967732; 22876277; 23421678; 24719266; 26993162; 32572027; 9655904 $$$$