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M  END
> <ID>
CHEBI:131163

> <NAME>
RGFP966

> <DEFINITION>
A member of the class of pyrazoles that is 1H-pyrazole substituted by (1E)-1-phenylprop-1-en-3-yl and (1E)-3-(2-amino-4-fluoroanilino)-3-oxoprop-1-en-1-yl groups at positions 1 and 4, respectively. It is a histone deacetylase 3 inhibitor.

> <STAR>
3

> <SYNONYM>
RGFP-966; RGFP 966; (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide; (2E)-N-(2-amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide

> <IUPAC_NAME>
(2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide

> <FORMULA>
C21H19FN4O

> <MASS>
362.408

> <MONOISOTOPIC_MASS>
362.15429

> <CHARGE>
0

> <SMILES>
NC1=C(NC(=O)\C=C\C2=CN(C\C=C\C3=CC=CC=C3)N=C2)C=CC(F)=C1

> <INCHI>
InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+

> <INCHIKEY>
BLVQHYHDYFTPDV-VCABWLAWSA-N

> <CAS_REGISTRY_NUMBER>
1396841-57-8

> <PUBMED_CITATION>
23297220; 26400942; 26993378; 27031333; 28928640; 29211617; 29860001; 30397132; 31914678; 32021097; 32585142; 32800772; 32893527; 33039815; 33359392; 33529911; 33639591; 34666303; 35947794; 36230643; 36258136; 36541629; 37539293; 37698830; 37890360; 37992448; 38176919; 38708192; 38733301

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