Ketcher 06212414422D 1 1.00000 0.00000 0 33 36 0 0 0 999 V2000 5.7868 -4.7493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6528 -4.2493 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.5189 -4.7493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5189 -5.7493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3849 -6.2493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2509 -5.7493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2509 -4.7493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3849 -4.2493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2020 -4.4404 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.7897 -5.2493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2020 -6.0584 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.5110 -7.0094 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9232 -7.8184 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5110 -8.6275 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4621 -8.3184 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4621 -7.3184 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 12.2711 -8.9063 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1665 -9.9008 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.1846 -8.4995 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.2020 -9.5785 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.2238 -9.7865 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9148 -10.7375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9366 -10.9454 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6276 -11.8965 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2968 -12.6397 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2749 -12.4317 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5839 -11.4806 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6528 -6.2493 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.7868 -5.7493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5621 -11.2727 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2312 -12.0159 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 10.8710 -10.3217 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 11.5402 -11.0648 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 2 3 1 0 0 0 3 4 2 0 0 0 4 5 1 0 0 0 5 6 2 0 0 0 6 7 1 0 0 0 7 8 2 0 0 0 8 3 1 0 0 0 7 9 1 0 0 0 9 10 2 0 0 0 10 11 1 0 0 0 11 6 1 0 0 0 11 12 1 0 0 0 12 13 2 0 0 0 13 14 1 0 0 0 14 15 2 0 0 0 15 16 1 0 0 0 16 12 1 0 0 0 15 17 1 0 0 0 17 18 2 0 0 0 17 19 1 0 0 0 14 20 1 0 0 0 20 21 1 0 0 0 21 22 1 0 0 0 22 23 2 0 0 0 23 24 1 0 0 0 24 25 2 0 0 0 25 26 1 0 0 0 26 27 2 0 0 0 27 22 1 0 0 0 4 28 1 0 0 0 28 29 1 0 0 0 27 30 1 0 0 0 30 31 1 0 0 0 30 32 1 0 0 0 30 33 1 0 0 0 M END > CHEBI:91334 > GW843682X > A member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl, methoxy, and methoxy groups at positions 1, 5, and 6, respectively. It is a potent inhibitor of PLK1 and PLK3 (IC50 = 2.2 and 9.1 nM respectively). > 3 > GW843682; GW-843682X; GW 843682X; 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide; 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide > 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide > C22H18F3N3O4S > 477.460 > 477.09701 > 0 > COC1=C(OC)C=C2N(C=NC2=C1)C1=CC(OCC2=CC=CC=C2C(F)(F)F)=C(S1)C(N)=O > InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29) > JSKUWFIZUALZLX-UHFFFAOYSA-N > 660868-91-7 > LSM-1014 > 17267659; 18616938; 19421227; 21436619; 21474997; 21637161; 23792639; 24205328; 26055176; 27198987; 36591293; 37181811; 38614382 $$$$