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M  END
> <ID>
CHEBI:125562

> <NAME>
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

> <DEFINITION>
A benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines.

> <STAR>
3

> <SYNONYM>
N-hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide; M344; M-344; histone deacetylase inhibitor III; D237; 4-dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide

> <IUPAC_NAME>
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

> <FORMULA>
C16H25N3O3

> <MASS>
307.389

> <MONOISOTOPIC_MASS>
307.18959

> <CHARGE>
0

> <SMILES>
CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

> <INCHI>
InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)

> <INCHIKEY>
MXWDSZWTBOCWBK-UHFFFAOYSA-N

> <REAXYS_REGISTRY_NUMBER>
8570090

> <DRUGBANK_ACCESSION>
DB02565

> <LINCS_ACCESSION>
LSM-37091

> <PUBMED_CITATION>
10579829; 11831887; 16263156; 16724231; 16773328; 20526416; 20828393; 21854619; 22436652; 23638461; 28380503; 29073110

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