Ketcher 02072215362D 1 1.00000 0.00000 0 31 35 0 1 0 999 V2000 9.5025 -38.9370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6365 -38.4370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3686 -38.4370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6366 -37.4369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3686 -37.4370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5026 -36.9370 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.3197 -38.7459 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.9074 -37.9370 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.3197 -37.1280 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.6288 -36.1769 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9597 -35.4338 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6070 -35.9691 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2689 -34.4827 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9161 -35.0181 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2470 -34.2749 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5562 -33.3239 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5343 -33.1161 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.8871 -32.5807 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.2034 -33.8593 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8434 -32.1650 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1744 -31.4218 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8216 -31.9572 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4835 -30.4708 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.1307 -31.0062 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4616 -30.2630 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1815 -33.6515 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8942 -34.8103 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.8506 -34.3948 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5633 -35.5536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5414 -35.3457 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4907 -32.7004 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 1 3 2 0 0 0 2 4 2 0 0 0 4 6 1 0 0 0 5 6 2 0 0 0 3 7 1 0 0 0 3 5 1 0 0 0 7 8 2 0 0 0 5 9 1 0 0 0 8 9 1 0 0 0 9 10 1 0 0 0 10 11 1 0 0 0 10 12 2 0 0 0 11 13 2 0 0 0 12 14 1 0 0 0 13 15 1 0 0 0 14 15 2 0 0 0 15 16 1 0 0 0 16 17 1 0 0 0 16 18 2 0 0 0 17 19 1 0 0 0 20 17 1 1 0 0 20 21 1 0 0 0 20 22 1 0 0 0 21 23 1 0 0 0 22 24 1 0 0 0 23 25 1 0 0 0 24 25 1 0 0 0 19 26 1 0 0 0 19 27 2 0 0 0 26 28 2 0 0 0 27 29 1 0 0 0 28 30 1 0 0 0 29 30 2 0 0 0 26 31 1 0 0 0 M END > CHEBI:189659 > PF-06446846 > A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. > 3 > PF06446846; PF-846; PF-06446846; PF 06446846 > N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide > C22H20ClN7O > 433.900 > 433.14179 > 0 > ClC1=CC=CN=C1N([C@@H]1CCCNC1)C(=O)C1=CC=C(C=C1)N1N=NC2=CC=CN=C12 > InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1 > FDTXHWQFIXYHCL-QGZVFWFLSA-N > 1632250-49-7 > MVM > 28323820; 29878763; 31160784; 31867167; 33009412; 33801308; 34359627 $$$$