Ketcher 05092409562D 1 1.00000 0.00000 0 26 30 0 1 0 999 V2000 11.4273 -6.0231 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0965 -6.7662 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0746 -6.5583 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7438 -7.3015 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7219 -7.0936 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.5309 -7.6814 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3400 -7.0936 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0309 -6.1426 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.0308 -6.1426 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3617 -5.3995 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3837 -5.6072 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7875 -7.7173 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8363 -8.0263 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9704 -7.5264 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1043 -8.0263 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1043 -9.0263 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9704 -9.5264 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8363 -9.0263 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7875 -9.3353 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3752 -8.5263 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.2383 -7.5264 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1338 -6.5319 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1556 -6.3240 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6555 -7.1900 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3248 -7.9330 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7489 -5.4104 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 1 0 0 2 3 1 0 0 0 3 4 2 0 0 0 4 5 1 0 0 0 5 6 1 0 0 0 6 7 2 0 0 0 7 8 1 0 0 0 8 9 2 0 0 0 9 5 1 0 0 0 9 10 1 0 0 0 10 11 2 0 0 0 11 3 1 0 0 0 2 12 1 0 0 0 12 13 1 0 0 0 13 14 2 0 0 0 14 15 1 0 0 0 15 16 2 0 0 0 16 17 1 0 0 0 17 18 2 0 0 0 18 13 1 0 0 0 18 19 1 0 0 0 19 20 2 0 0 0 20 12 1 0 0 0 15 21 1 0 0 0 21 22 2 0 0 0 22 23 1 0 0 0 23 24 1 0 0 0 24 25 2 0 0 0 25 21 1 0 0 0 23 26 1 0 0 0 M END > CHEBI:231369 > savolitinib > A member of the class of triazolopyrazines that is 1H-[1,2,3]triazolo[4,5-b]pyrazine substituted by (1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl and 1-methyl-1H-pyrazol-4-yl groups at positions 1 and 6, respectively. It is a highly selective MET tyrosine kinase inhibitor that is approved in China for advanced NSCLC with MET exon 14 skipping mutations. > 3 > volitinib; HMPL-504; HMPL 504; HM-5016504; HM 5016504; AZD6094; AZD-6094; AZD 6094; 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine; 1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine > 1-[(1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine > savolitinibum; savolitinib; savolitinib; savolitinib > Orpathys > C17H15N9 > 345.370 > 345.14504 > 0 > C[C@H](N1N=NC2=NC=C(N=C12)C1=CN(C)N=C1)C1=CN2C=CN=C2C=C1 > InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 > XYDNMOZJKOGZLS-NSHDSACASA-N > 1313725-88-0 > DB12048 > D11139 > V0L > Savolitinib > 25148209; 25779944; 28644771; 29191878; 30952639; 31531204; 31564914; 32027846; 32469384; 33052556; 33125717; 33400845; 34455538; 34590028; 36333268; 36339926; 36551608; 36808891; 36809050; 36811415; 36846984; 36888921; 36944506; 37078211; 37293311; 37315260; 37564044; 37835402; 38023194; 38145112; 38181277; 38182507; 38276867; 38313385; 38380365; 38385995; 38525101; 38599970 $$$$