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M  END
> <ID>
CHEBI:85990

> <NAME>
panobinostat

> <DEFINITION>
A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.

> <STAR>
3

> <SYNONYM>
LBH589; LBH 589

> <IUPAC_NAME>
(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide

> <INN>
panobinostat

> <FORMULA>
C21H23N3O2

> <MASS>
349.42620

> <MONOISOTOPIC_MASS>
349.17903

> <CHARGE>
0

> <SMILES>
Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1

> <INCHI>
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+

> <INCHIKEY>
FPOHNWQLNRZRFC-ZHACJKMWSA-N

> <CAS_REGISTRY_NUMBER>
404950-80-7

> <REAXYS_REGISTRY_NUMBER>
12257756

> <CHEMIDPLUS>
404950-80-7

> <KEGG_DRUG_ACCESSION>
D10319

> <WIKIPEDIA_ACCESSION>
Panobinostat

> <PUBMED_CITATION>
25305451; 25377157; 25410127; 25458954; 25572329; 25608569; 25612941; 25628765; 25710456; 25802326; 25837990; 25870990; 25904215; 25939707; 25944617; 26000292; 26030093; 26051506

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