Ketcher 07201616322D 1   1.00000     0.00000     0

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M  END
> <ID>
CHEBI:132754

> <NAME>
dynasore

> <DEFINITION>
A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.

> <STAR>
3

> <SYNONYM>
Dynamin Inhibitor I; 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

> <IUPAC_NAME>
N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide

> <FORMULA>
C18H14N2O4

> <MASS>
322.315

> <MONOISOTOPIC_MASS>
322.09536

> <CHARGE>
0

> <SMILES>
C=1C2=C(C=CC1)C=C(C(=C2)C(N/N=C/C=3C=C(C(=CC3)O)O)=O)O

> <INCHI>
InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

> <INCHIKEY>
SYNDQCRDGGCQRZ-VXLYETTFSA-N

> <CAS_REGISTRY_NUMBER>
304448-55-3

> <REAXYS_REGISTRY_NUMBER>
25249841

> <PUBMED_CITATION>
18413242; 23596510; 24367704; 25421092; 25550455; 25850711; 25878109; 25889964; 26063501; 26894834

$$$$