Ketcher 04081915212D 1 1.00000 0.00000 0 38 42 0 0 0 999 V2000 22.1107 -10.4415 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2431 -9.9096 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2431 -8.9021 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.3755 -8.4207 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5136 -8.9021 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5136 -9.9096 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.3755 -10.4415 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1107 -11.4041 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 22.9782 -9.9096 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 23.8459 -10.4415 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.8459 -11.4041 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 24.7079 -11.9358 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 25.5756 -11.4041 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 25.5756 -10.4415 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 24.7079 -9.9096 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 26.4431 -11.9358 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 26.4431 -12.9434 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 27.3106 -13.4248 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 27.3106 -14.4380 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 26.4431 -14.9194 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 25.5756 -14.4380 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 24.7079 -14.9194 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.8459 -14.4380 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.8459 -13.4248 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 24.7079 -12.9434 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 25.5756 -13.4248 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.9782 -12.9434 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 22.9782 -14.9194 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 22.1107 -14.4380 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2431 -14.9194 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.3755 -14.4380 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5136 -14.9194 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 19.5136 -15.9326 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.6458 -16.4586 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7784 -15.9326 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 17.7784 -14.9194 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.6458 -14.4380 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1275 -13.4541 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 2 3 1 0 0 0 3 4 2 0 0 0 4 5 1 0 0 0 5 6 2 0 0 0 6 7 1 0 0 0 2 7 2 0 0 0 1 8 2 0 0 0 1 9 1 0 0 0 9 10 1 0 0 0 10 11 1 0 0 0 11 12 2 0 0 0 12 13 1 0 0 0 13 14 2 0 0 0 14 15 1 0 0 0 10 15 2 0 0 0 13 16 1 0 0 0 16 17 1 0 0 0 18 17 1 0 0 0 19 18 2 0 0 0 20 19 1 0 0 0 20 21 2 0 0 0 22 21 1 0 0 0 23 22 2 0 0 0 24 23 1 0 0 0 25 24 2 0 0 0 26 25 1 0 0 0 17 26 2 0 0 0 26 21 1 0 0 0 24 27 1 0 0 0 23 28 1 0 0 0 28 29 1 0 0 0 29 30 1 0 0 0 30 31 1 0 0 0 31 32 1 0 0 0 33 32 1 0 0 0 34 33 1 0 0 0 35 34 1 0 0 0 35 36 1 0 0 0 37 36 1 0 0 0 32 37 1 0 0 0 27 38 1 0 0 0 M END > CHEBI:91376 > ZM447439 > A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC50 of 110 nM and 130 nM, respectively. > 3 > ZM447439; ZM-447439; ZM 447439; N-[4-[[6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl]amino]phenyl]benzamide; N-(4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinazolinyl)amino)phenyl)benzamide > N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide > C29H31N5O4 > 513.598 > 513.23760 > 0 > C(C=1C=CC=CC1)(=O)NC=2C=CC(=CC2)NC=3N=CN=C4C=C(C(=CC34)OC)OCCCN5CCOCC5 > InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) > OGNYUTNQZVRGMN-UHFFFAOYSA-N > 331771-20-1 > 331771-20-1 > LSM-1096 > 2VRX > 447 > ZM447439 > 12719470; 15616188; 18367484; 18418083; 18559266; 19298889; 19686703; 19923785; 21099354; 21159048; 21775627; 23613471; 24152827; 24680981; 24748653; 29147452 $$$$